The year 2022 was a pivotal year where numerous states took significant action to safeguard human and environmental health from toxic chemicals and pushed toward a system based on safer chemicals and materials. Given the urgency of the PFAS chemical crisis contaminating drinking water across the country, states drove an ambitious agenda, pushing for class-based restriction of toxic chemicals, transparency about what chemicals are in what products, holding polluters accountable, preventing false solutions, and investing in cleanup.